Resumen
Breast cancer is a complex disease that remains a significant public health challenge. The breast cancer cells secrete various substances collectively known as the secretome, which include proteins, lipids, and nucleic acids that contribute to the growth and spread of breast cancer. The secretome plays a crucial role in the development and progression of breast cancer by modifying signaling pathways and creating an environment supporting cancer growth while evading the immune system. Additionally, the secretome is responsible for the development of resistance to cancer drugs, making it a significant challenge for effective treatment. Therefore, understanding the role of the secretome in breast cancer is essential for developing innovative therapies. This review provides insights into the impact of the secretome on breast cancer progression and its interactions with the tumor microenvironment, and explores potential therapeutic opportunities targeting the secretome components. By identifying specific molecules and signaling pathways involved in the secretome, new targets for therapeutic intervention can be identified, which can ultimately improve outcomes for breast cancer patients.