Resumen
Colorectal cancer remains the second leading cause of cancer-related death worldwide, which is a situation that requires the continuous search for natural bioactive compounds that can mitigate its effects or can be used as co-adjuvants in the frame of precision nutrition. The elucidation of the mechanisms underlying the bioenergetics of colorectal tumorous cells as well as the modulation of lipid metabolism-related genes may greatly contribute to personalized therapies. We show that saponin- and sapogenin-rich extracts from fenugreek are able to strongly inhibit colorectal cancer cells? growth, which is related to a reduction in the mitochondrial oxidative phosphorylation and the inhibition of aerobic glycolysis, in which each of the extracts target the molecular pathways related to lipid metabolism in a different manner. We propose that this outcome may have important implications on their potential use against colon cancer in the context of precision nutrition.