Inicio  /  Cancers  /  Vol: 15 Par: 9 (2023)  /  Artículo
ARTÍCULO
TITULO

Automated Deep Learning-Based Classification of Wilms Tumor Histopathology

Ananda van der Kamp    
Thomas de Bel    
Ludo van Alst    
Jikke Rutgers    
Marry M. van den Heuvel-Eibrink    
Annelies M. C. Mavinkurve-Groothuis    
Jeroen van der Laak and Ronald R. de Krijger    

Resumen

Wilms tumor (WT) is the most frequent pediatric tumor in children and shows highly variable histology, leading to variation in classification. Artificial intelligence-based automatic recognition holds the promise that this may be done in a more consistent way than human observers can. We have therefore studied digital microscopic slides, stained with standard hematoxylin and eosin, of 72 WT patients and used a deep learning (DL) system for the recognition of 15 different normal and tumor components. We show that such DL system can do this task with high accuracy, as exemplified by a Dice score of 0.85 for the 15 components. This approach may allow future automated WT classification.

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