Resumen
Bladder urothelial carcinoma (BLCA) arises from basal cells that develop dysplasia and carcinoma in situ and, if unchecked, progress to invasion and metastases. Major players underlying the molecular mechanisms of invasive and metastatic BLCA are yet to be determined. Annexin A2 (AnxA2), a Ca++-dependent phospholipid-binding protein, is overexpressed in various cancers and facilitates cell migration and invasion. This study established a correlation between AnxA2 and BLCA using existing BLCA data from the Cancer Genome Atlas (TCGA). In addition, we determined its role in the proliferation, migration, and invasion of metastatic bladder cancer cells.