Resumen
Human gastrointestinal lymphomas are rare diseases with an incidence of one per 1,000,000 inhabitants per year. This paucity poses a major challenge in unravelling their underlying mechanism. In comparison, lymphoma is the most common malignancy in domestic cats and the gastrointestinal (GI) tract is the most common location for this disease. Here, we identify the driver mutation STAT5BN642H in feline alimentary lymphoma, thereby establishing felines as a potential new model for a rare and incurable human T cell disease.