Resumen
The prognosis and treatment of metastatic melanoma have changed substantially since the advent of target therapy and immune checkpoint inhibitors. Thus, strategies must be developed to identify responder patients, reduce toxicities, and investigate target and immune based therapy ideal sequencing. To this aim, the determinants driving response, resistance, and adverse events, should be defined. In addition, novel oncogenic drivers should be discovered to provide new therapeutic targets. Current methods of detection, prognosis and monitoring of melanoma are based on clinical, morphological and histopathologic characteristics of the tumor. This review provides an update on prognostic and predictive biomarkers with a potential application in melanoma patients? clinical management.