Resumen
As one of most malignant tumors in brain, glioblastoma (GBM) is lack of effective treatment and the prognosis of GBM patients is still very poor despite accumulated progresses. Hypoxia is an essential factor for the initiation and progression of GBM, especially for the glioma stem like cells (GSCs). Hypoxia induced many target genes which form a complicated molecular interacting network, influencing a lot of tumor behaviors by regulating key signal pathways. In addition, hypoxia has great impact on the interplayed niches of GCSs. Here, by systematically reviewing the role of hypoxia on the maintenance of GSCs and the development of GBM, and analyzing the related molecular mechanisms, we integrated the hypoxia related tumor features of GBM. This summary helps to deepen our knowledge of the tumorigenic mechanisms of GBM, and can help to develop novel therapeutic strategies targeting hypoxia to improve the survival of GBM patients.