Resumen
Renal cancers are common types of tumors affecting humans. While many different genes have been found to be mutated and to drive the initiation and progression of these lethal cancers, a fine molecular understanding of the process is still lacking. One important pathway that emerges central in many different types of renal cancers is one called KEAP-NRF2. This axis is very important in normal kidneys as a defense against oxidative stress. Here, we summarize a large body of literature suggesting that this axis is exploited by tumor cells to escape control and to transform, and thus it could represent a good target for therapy.