Resumen
Biomarker-guided therapies offer the possibility for targeted cancer therapies. For gastric cancer, HER2 plays a pivotal role. To date, with trastuzumab and trastuzumab-deruxtecan, two HER2-targeting options exist for the treatment of metastatic HER2-positive gastric cancer. However, these therapies rarely lead to long-lasting results as resistance mechanisms and heterogeneity limit their success. This review gives an overview of the current standard-of-care treatment of HER2-positive gastric cancer and new developments in the field.