Resumen
Fusion proteins are an important class of oncogenes in sarcoma. Approximately 40 percent of all sarcoma entities are driven by one of the more than 100 known fusion proteins. Individual fusion proteins belong to different protein classes, including transcription factors, epigenetic regulators and kinases, and are characterized by specific mechanisms of action. Here, we summarize the current knowledge on fusion oncogenes in sarcoma, highlighting the differences as well as similarities in their biology. Overall, this work provides the basis for a functional classification of sarcomas.