Inicio  /  Cancers  /  Vol: 15 Par: 17 (2023)  /  Artículo
ARTÍCULO
TITULO

Comparing Liver Venous Deprivation and Portal Vein Embolization for Perihilar Cholangiocarcinoma: Is It Time to Shift the Focus to Hepatic Functional Reserve Rather than Hypertrophy?

Rebecca Marino    
Francesca Ratti    
Angelo Della Corte    
Domenico Santangelo    
Lucrezia Clocchiatti    
Carla Canevari    
Patrizia Magnani    
Federica Pedica    
Andrea Casadei-Gardini    
Francesco De Cobelli and Luca Aldrighetti    

Resumen

Liver venous deprivation (LVD) has emerged as a promising technique in the pursuit of improving surgical outcomes for perihilar cholangiocarcinoma (PHC) patients. This procedure, which combines portal inflow and hepatic outflow abrogation, has generated significant clinical interest. However, its specific role in optimizing the future liver remnant (FLR) before liver resection, especially when compared to portal vein embolization (PVE), remains unclear. Between 2013 and 2022, all patients with PHC undergoing preoperative FLR enhancement were evaluated. FLR volume assessments were conducted at two time points to evaluate early and late efficacy indicators. While both LVD and PVE cohorts experienced similar post-procedural complications, LVD demonstrated superior FLR function and growth rates at both assessment points. This suggests faster recovery and improved remnant liver functionality. Although FLR volumes remained comparable between the techniques, LVD emerged as an effective method for optimizing FLR in PHC, potentially enhancing liver function and reducing post-hepatectomy liver failure rates, thus improving overall surgical outcomes.

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