Resumen
It is well-known that ovarian clear cell carcinoma presents unique molecular traits in comparison to other ovarian cancer subtypes, partially reflecting on chemotherapy resistance. Here, by investigating a panel of cancer-associated genes in a Danish population, our data showed that patients were further stratified into four different molecular subgroups: ?PIK3CA?, ?ARID1A?, ?PIK3CA-ARID1A? and ?Undetermined?, in regard to the presence of mutation on these genes. Somatic signature investigation further revealed that those subgroups share common features, such as ageing and defective MMR, whilst also bearing unique signatures. These findings suggest that different groups possess specific molecular backgrounds, indicating that such individuals could better benefit from more individualized therapy regimens.