Resumen
The Wnt/ß-catenin signaling pathway is aberrantly activated in most colorectal cancers and less frequently in a variety of other solid neoplasias. Many epidemiological and experimental studies and some clinical trials suggest an anticancer action of vitamin D, mainly against colorectal cancer. The aim of this review was to analyze the literature supporting the interference of Wnt/ß-catenin signaling by the active vitamin D metabolite 1a,25-dihydroxyvitamin D3. We discuss the molecular mechanisms of this antagonism in colorectal cancer and other cancer types. Additionally, we summarize the available data indicating a reciprocal inhibition of vitamin D action by the activated Wnt/ß-catenin pathway. Thus, a complex mutual antagonism between Wnt/ß-catenin signaling and the vitamin D system seems to be at the root of many solid cancers.