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Inicio  /  Applied Sciences  /  Vol: 9 Par: 13 (2019)  /  Artículo
ARTÍCULO
TITULO

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

Arina A. Chepanova    
Evgenii S. Mozhaitsev    
Aldar A. Munkuev    
Evgeniy V. Suslov    
Dina V. Korchagina    
Olga D. Zakharova    
Alexandra L. Zakharenko    
Jinal Patel    
Daniel M. Ayine-Tora    
Jóhannes Reynisson    
Ivanhoe K. H. Leung    
Konstantin P. Volcho    
Nariman F. Salakhutdinov and Olga I. Lavrik    

Resumen

Inhibition of Tdp1 has the potential to increase the potency of the anticancer drugs topotecan and irinotecan, topoisomerase 1 poisons. Furthermore, Tdp1 inhibitors can facilitate the therapeutic use of these drugs in other cancer types.

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