Inicio  /  Cancers  /  Vol: 13 Par: 13 (2021)  /  Artículo
ARTÍCULO
TITULO

Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer

João Alfredo Moraes    
Carol Encarnação    
Victor Aguiar Franco    
Luiz Gabriel Xavier Botelho    
Gabriella Pacheco Rodrigues    
Isadora Ramos-Andrade    
Christina Barja-Fidalgo and Mariana Renovato-Martins    

Resumen

Increased body fat is associated with an increased risk of 13 different cancer types. Recent findings have demonstrated a close relationship between extracellular vesicles released by adipose tissues and the establishment and progression of several types of cancers and metastasis. However, detailed information about the establishment of such cooperation is still lacking. We provide evidence to support that extracellular vesicles secreted by adipose tissues may carry tumoral molecules that modulate the behavior and functions of cancer cells, as described in the seminal report ?The Hallmarks of Cancer? by Hanahan and Weinberg, published in the early 2000s.

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