Resumen
Recent genomic analytical advancements have revealed that BRCA1/2 pathogenic variants are the most frequent mutations among DNA damage repair genes in prostate cancer. Polyadenosine diphosphatase ribose polymerase (PARP) inhibitor, olaparib, has been shown as an effective therapeutic option for the disease. This review focuses on PARP inhibitors? basic and clinical mechanisms of action against prostate cancer and discusses their effects on the tumor microenvironment.