The maximum power point tracking (MPPT) algorithms ensure optimal operation of a photovoltaic (PV) system to extract the maximum PV power, regardless of the climatic conditions. This paper exposes the study, design, simulation and implementation of a modified advanced neural fuzzy inference system (ANFIS) MPPT algorithm based on fuzzy data for a PV system. The studied system includes a PV array, a DC/DC buck converter, the ANFIS controller, a proportional-integral (PI) controller, and a load. The simulation and experimental tests are carried out with the MATLAB/Simulink software and LabVIEW, respectively. Moreover, the obtained results are compared with previously published results by incremental conductance (IC) and fuzzy logic (FL) algorithms under different climatic conditions of irradiation and temperature. The results show that the proposed ANFIS algorithm is able to track the maximum power point for varying climatic conditions. Furthermore, the comparison analysis reveals that the PV system using ANFIS algorithm has more efficient and better dynamic response than FL and IC.