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Cosmin Trif, Dragos Paul Mihai, Anca Zanfirescu and George Mihai Nitulescu
The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field. In o...
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Yanhong Lin, Jing Wang, Xiaolin Li, Yuanzi Zhang and Shiguo Huang
Quantitative Structure?Activity Relationship (QSAR) aims to correlate molecular structure properties with corresponding bioactivity. Chance correlations and multicollinearity are two major problems often encountered when generating QSAR models. Feature s...
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Melanie Voigt, Benjamin Hentschel, Nina Theiss, Christina Savelsberg, Indra Bartels, Anna Nickisch-Hartfiel and Martin Jaeger
Pharmaceuticals in waters represent a worldwide problem of today. Advanced oxidation processes (AOPs) are being researched for elimination of the ecological hazard. Among the substances, the fluoroquinolone antibiotic lomefloxacin was selected for invest...
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Dragos Paul Mihai, Cosmin Trif, Gheorghe Stancov, Denise Radulescu and George Mihai Nitulescu
Transient receptor potential ankyrin 1 (TRPA1) is a ligand-gated calcium channel activated by cold temperatures and by a plethora of electrophilic environmental irritants (allicin, acrolein, mustard-oil) and endogenously oxidized lipids (15-deoxy-?12, 14...
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