Resumen
Epithelial ovarian cancer (EOC) is the deadliest cancer in the female reproductive system. Currently, there are no effective early detection methods for this disease, and the treatments for advanced stages of EOC have a low success rate. Circular RNAs (circRNAs) are noncoding RNAs generated from the ?back-splicing? of precursor messenger RNAs. Recent studies have shown that many circRNAs are aberrantly expressed in tumor tissues and/or plasma of EOC patients, and they regulate EOC cell activity and tumor growth. In this review, we provide an overview of EOC and circRNA biology. We then summarize circRNAs that are dysregulated and exert tumor-promoting or tumor-suppressive effects in EOC. We also discuss the possibility of using circRNAs as diagnostic/prognostic markers and therapeutic targets.