The impacts of temperature and precipitation changes on regional evaporation and runoff characteristics have been investigated for the Biliu River basin, which is located in Liaoning Province, northeast China. Multiple climate change scenarios from phase 3 and phase 5 of the Coupled Model Intercomparison Project (CMIP3 and CMIP5) (21 scenarios in total) were utilized. A calibrated hydrologic model?SWAT model?was used to simulate future discharges based on downscaled climate data through a validated morphing method. Results show that both annual temperature and precipitation increase under most of the CMIP3 and CMIP5 scenarios, and increase more in the far future (2041?2065) than in the near future (2016?2040). These changes in precipitation and temperature lead to an increase in evaporation under 19 scenarios and a decrease in runoff under two-thirds of the selected scenarios. Compared to CMIP3, CMIP5 scenarios show higher temperature and wider ranges of changes in precipitation and runoff. The results provide important information on the impacts of global climate change on water resources availability in the Biliu River basin, which is beneficial for the planning and management of water resources in this region.